Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.

Yoshikawa, Noriko; Yamada, Shizuo; Takeuchi, Chihiro; Kagota, Satomi; Shinozuka, Kazumasa; Kunitomo, Masaru; Nakamura, Kazuki

Yoshikawa, Noriko; Yamada, Shizuo; Takeuchi, Chihiro; Kagota, Satomi; Shinozuka, Kazumasa; Kunitomo, Masaru; Nakamura, Kazuki.

Affiliation

Yoshikawa N; Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo, 663-8179, Japan.

Naunyn Schmiedebergs Arch Pharmacol ; 377(4-6): 591-5, 2008 Jun.

Article in En | MEDLINE | ID: mdl-18084742

Subject(s)

Antineoplastic Agents/pharmacology; Deoxyadenosines/pharmacology; Melanoma, Experimental/drug therapy; Receptor, Adenosine A3/drug effects; Animals; Antineoplastic Agents/isolation & purification; Cell Line, Tumor; Cell Proliferation/drug effects; Cordyceps/chemistry; Cyclin D1/antagonists & inhibitors; Deoxyadenosines/isolation & purification; Gene Expression; Glycogen Synthase Kinase 3/drug effects; Glycogen Synthase Kinase 3/metabolism; Glycogen Synthase Kinase 3 beta; Melanoma, Experimental/physiopathology; Mice; Protein Binding; Radioligand Assay; Receptor, Adenosine A3/metabolism; Signal Transduction; Wnt Proteins/metabolism

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Deoxyadenosines / Receptor, Adenosine A3 / Antineoplastic Agents Limits: Animals Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2008 Type: Article Affiliation country: Japan

Search on Google

XML

PubMed Links