PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: a mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment.

Guénin, Samuel; Schwartz, Laurent; Morvan, Daniel; Steyaert, Jean Marc; Poignet, Amandine; Madelmont, Jean Claude; Demidem, Aicha

Guénin, Samuel; Schwartz, Laurent; Morvan, Daniel; Steyaert, Jean Marc; Poignet, Amandine; Madelmont, Jean Claude; Demidem, Aicha.

Affiliation

Guénin S; UMR INSERM 484, 63005 Cedex Clermont-Ferrand, France.

Int J Oncol ; 32(1): 49-57, 2008 Jan.

Article in En | MEDLINE | ID: mdl-18097542

Subject(s)

Antineoplastic Agents/pharmacology; Melanoma, Experimental/drug therapy; Nitrosourea Compounds/pharmacology; Protein Phosphatase 2/metabolism; Animals; DNA Damage; Melanoma, Experimental/pathology; Methylation; Mice; Mice, Inbred C57BL; Okadaic Acid/pharmacology; PTEN Phosphohydrolase/metabolism; Pentosephosphates/pharmacology; Proto-Oncogene Proteins c-akt/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Protein Phosphatase 2 / Antineoplastic Agents / Nitrosourea Compounds Limits: Animals Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2008 Type: Article Affiliation country: France

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