TORC1 is essential for NF1-associated malignancies.

Johannessen, Cory M; Johnson, Bryan W; Williams, Sybil M Genther; Chan, Annie W; Reczek, Elizabeth E; Lynch, Ryan C; Rioth, Matthew J; McClatchey, Andrea; Ryeom, Sandra; Cichowski, Karen

Johannessen, Cory M; Johnson, Bryan W; Williams, Sybil M Genther; Chan, Annie W; Reczek, Elizabeth E; Lynch, Ryan C; Rioth, Matthew J; McClatchey, Andrea; Ryeom, Sandra; Cichowski, Karen.

Affiliation

Johannessen CM; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Ludwig Center at Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

Curr Biol ; 18(1): 56-62, 2008 Jan 08.

Article in En | MEDLINE | ID: mdl-18164202

Subject(s)

Genes, Neurofibromatosis 1; Neoplasms/genetics; Transcription Factors/physiology; Animals; Cell Line; Cyclin D; Cyclins/genetics; Cyclins/metabolism; Disease Models, Animal; Gene Expression Regulation/drug effects; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms/metabolism; Protein Kinase Inhibitors/pharmacology; Protein Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Sirolimus/pharmacology; TOR Serine-Threonine Kinases; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Genes, Neurofibromatosis 1 / Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2008 Type: Article Affiliation country: United States

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