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BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Clarke, Brian; Demont, Emmanuel; Dingwall, Colin; Dunsdon, Rachel; Faller, Andrew; Hawkins, Julie; Hussain, Ishrut; MacPherson, David; Maile, Graham; Matico, Rosalie; Milner, Peter; Mosley, Julie; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Riddell, David; Rowland, Paul; Soleil, Virginie; Smith, Kathrine J; Stanway, Steven; Stemp, Geoffrey; Sweitzer, Sharon; Theobald, Pam; Vesey, David; Walter, Daryl S; Ward, John; Wayne, Gareth.
Affiliation
  • Clarke B; Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom.
Bioorg Med Chem Lett ; 18(3): 1017-21, 2008 Feb 01.
Article in En | MEDLINE | ID: mdl-18166458
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspartic Acid Endopeptidases / Combinatorial Chemistry Techniques / Ethylamines / Amyloid Precursor Protein Secretases / Alzheimer Disease Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspartic Acid Endopeptidases / Combinatorial Chemistry Techniques / Ethylamines / Amyloid Precursor Protein Secretases / Alzheimer Disease Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United kingdom