Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model.

Halstead, Susan K; Zitman, Femke M P; Humphreys, Peter D; Greenshields, Kay; Verschuuren, Jan J; Jacobs, Bart C; Rother, Russell P; Plomp, Jaap J; Willison, Hugh J

Halstead, Susan K; Zitman, Femke M P; Humphreys, Peter D; Greenshields, Kay; Verschuuren, Jan J; Jacobs, Bart C; Rother, Russell P; Plomp, Jaap J; Willison, Hugh J.

Affiliation

Halstead SK; University of Glasgow, Division of Clinical Neurosciences, Glasgow Biomedical Research Centre, Glasgow, UK.

Brain ; 131(Pt 5): 1197-208, 2008 May.

Article in En | MEDLINE | ID: mdl-18184663

Subject(s)

Antibodies, Monoclonal/therapeutic use; Miller Fisher Syndrome/prevention & control; Nervous System Autoimmune Disease, Experimental/prevention & control; Animals; Antibodies, Monoclonal, Humanized; Complement Activation/immunology; Disease Models, Animal; Drug Evaluation, Preclinical/methods; Gangliosides/immunology; Male; Mice; Mice, Inbred BALB C; Miller Fisher Syndrome/immunology; Miller Fisher Syndrome/physiopathology; Muscle Contraction; Nervous System Autoimmune Disease, Experimental/immunology; Nervous System Autoimmune Disease, Experimental/physiopathology; Neuromuscular Junction/immunology; Neuromuscular Junction/physiopathology; Respiratory Paralysis/immunology; Respiratory Paralysis/physiopathology; Respiratory Paralysis/prevention & control; Synapses/ultrastructure; Tissue Culture Techniques

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Miller Fisher Syndrome / Nervous System Autoimmune Disease, Experimental / Antibodies, Monoclonal Limits: Animals Language: En Journal: Brain Year: 2008 Type: Article Affiliation country: United kingdom

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