Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal.

Chiu, Jenny D; Richey, Joyce M; Harrison, L Nicole; Zuniga, Edward; Kolka, Cathryn M; Kirkman, Erlinda; Ellmerer, Martin; Bergman, Richard N

Chiu, Jenny D; Richey, Joyce M; Harrison, L Nicole; Zuniga, Edward; Kolka, Cathryn M; Kirkman, Erlinda; Ellmerer, Martin; Bergman, Richard N.

Affiliation

Chiu JD; Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, 1333 San Pablo St., MMR 626, Los Angeles, CA 90033, USA.

Diabetes ; 57(4): 828-35, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18223011

Subject(s)

Capillaries/physiology; Endothelium, Vascular/physiology; Glucose/metabolism; Insulin/pharmacology; Insulin/physiology; Muscle, Skeletal/blood supply; Muscle, Skeletal/physiology; Animals; Biological Transport; Dogs; Glucose/administration & dosage; Glucose Clamp Technique; Infusions, Intravenous; Injections, Intramuscular; Insulin/administration & dosage; Male; Muscle, Skeletal/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capillaries / Endothelium, Vascular / Muscle, Skeletal / Glucose / Insulin Limits: Animals Language: En Journal: Diabetes Year: 2008 Type: Article Affiliation country: United States

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