Sonication induced intermediate in prion protein conversion.
Protein Pept Lett
; 15(2): 206-11, 2008.
Article
in En
| MEDLINE
| ID: mdl-18289112
ABSTRACT
We have observed that hamster prion protein (PrP(C)) undergoes conformational changes on exposure to heat or sonication. If a sonication induced new conformer is seeded with a small amount of its abnormal pathogenic isoform (PrP(Sc)) it undergoes a significant conversion to a proteinase-resistant isoform. This suggests the presence of a third stable PrP conformer, which may be intermediate in the conversion of PrP(C) to PrP(Sc).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Conformation
/
Sonication
/
PrPSc Proteins
/
PrPC Proteins
/
Protein Isoforms
Limits:
Animals
Language:
En
Journal:
Protein Pept Lett
Journal subject:
BIOQUIMICA
Year:
2008
Type:
Article
Affiliation country:
United States