The Notch pathway in podocytes plays a role in the development of glomerular disease.

Niranjan, Thiruvur; Bielesz, Bernhard; Gruenwald, Antje; Ponda, Manish P; Kopp, Jeffrey B; Thomas, David B; Susztak, Katalin

Niranjan, Thiruvur; Bielesz, Bernhard; Gruenwald, Antje; Ponda, Manish P; Kopp, Jeffrey B; Thomas, David B; Susztak, Katalin.

Affiliation

Niranjan T; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA.

Nat Med ; 14(3): 290-8, 2008 Mar.

Article in En | MEDLINE | ID: mdl-18311147

Subject(s)

Diabetic Nephropathies/metabolism; Glomerulosclerosis, Focal Segmental/metabolism; Podocytes/metabolism; Receptors, Notch/metabolism; Animals; Apoptosis/drug effects; Apoptosis/physiology; Dibenzazepines/pharmacology; Female; Gene Deletion; Gene Expression Regulation; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics; Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism; Male; Mice; Mice, Transgenic; Naphthalenes; Nephrotic Syndrome/chemically induced; Nephrotic Syndrome/drug therapy; Nephrotic Syndrome/metabolism; Protein Structure, Tertiary; Pyridines; Rats; Receptors, Notch/antagonists & inhibitors; Receptors, Notch/genetics; Transforming Growth Factor beta1/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glomerulosclerosis, Focal Segmental / Diabetic Nephropathies / Podocytes / Receptors, Notch Limits: Animals / Female / Humans / Male Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2008 Type: Article Affiliation country: United States

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