Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients.
Clin Biochem
; 41(7-8): 511-8, 2008 May.
Article
in En
| MEDLINE
| ID: mdl-18313403
ABSTRACT
OBJECTIVES:
To evaluate the oxidative status and antioxidant defense in patients with acute lymphoblastic leukemia (ALL). DESIGN ANDMETHODS:
We measured concentrations of plasmatic thiobarbituric acid reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities, as well as the plasmatic and erythrocyte thiol levels and serum vitamin E concentration. This study was performed on 80 children with ALL divided into 4 groups just diagnosed, remission induction, remission maintenance and out-of-treatment.RESULTS:
TBARS levels and serum protein carbonylation were higher in ALL patients than in controls and reduced levels of antioxidants were found in these patients.CONCLUSION:
These findings may indicate a possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage, supporting the idea that there is a persistence of oxidative stress in acute lymphoblastic leukemia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxidative Stress
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Antioxidants
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Biochem
Year:
2008
Type:
Article
Affiliation country:
Brazil