Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.

Strainic, Michael G; Liu, Jinbo; Huang, Danping; An, Fengqi; Lalli, Peter N; Muqim, Nasima; Shapiro, Virginia S; Dubyak, George R; Heeger, Peter S; Medof, M Edward

Strainic, Michael G; Liu, Jinbo; Huang, Danping; An, Fengqi; Lalli, Peter N; Muqim, Nasima; Shapiro, Virginia S; Dubyak, George R; Heeger, Peter S; Medof, M Edward.

Affiliation

Strainic MG; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

Immunity ; 28(3): 425-35, 2008 Mar.

Article in En | MEDLINE | ID: mdl-18328742

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Cell Survival/immunology; Complement C3a/immunology; Complement C5a/immunology; Lymphocyte Activation/immunology; Animals; Antigen Presentation/immunology; Antigen-Presenting Cells/immunology; B7-1 Antigen/immunology; B7-1 Antigen/metabolism; CD28 Antigens/immunology; CD28 Antigens/metabolism; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/metabolism; CD40 Antigens/immunology; CD40 Antigens/metabolism; CD40 Ligand/immunology; CD40 Ligand/metabolism; Cell Differentiation/immunology; Complement C3a/metabolism; Complement C5a/metabolism; Flow Cytometry; Immunoblotting; Immunoprecipitation; Mice; Mice, Transgenic; Polymerase Chain Reaction; RNA, Messenger/analysis; Receptor, Anaphylatoxin C5a/immunology; Receptor, Anaphylatoxin C5a/metabolism; Signal Transduction/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / CD4-Positive T-Lymphocytes / Complement C3a / Complement C5a / Cell Survival Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2008 Type: Article Affiliation country: United States

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