Your browser doesn't support javascript.
loading
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.
Haldar, Manas K; Scott, Michael D; Sule, Nitesh; Srivastava, D K; Mallik, Sanku.
Affiliation
  • Haldar MK; Department of Pharmaceutical Sciences, North Dakota State University, 1401 Albrecht Boulevard, Fargo, ND 58105, USA.
Bioorg Med Chem Lett ; 18(7): 2373-6, 2008 Apr 01.
Article in En | MEDLINE | ID: mdl-18343108
ABSTRACT
The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Barbiturates / Escherichia coli / Aminopeptidases Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Barbiturates / Escherichia coli / Aminopeptidases Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United States