Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion.

Carbonaro, Denise A; Jin, Xiangyang; Cotoi, Daniel; Mi, Tiejuan; Yu, Xiao-Jin; Skelton, Dianne C; Dorey, Frederick; Kellems, Rodney E; Blackburn, Michael R; Kohn, Donald B

Carbonaro, Denise A; Jin, Xiangyang; Cotoi, Daniel; Mi, Tiejuan; Yu, Xiao-Jin; Skelton, Dianne C; Dorey, Frederick; Kellems, Rodney E; Blackburn, Michael R; Kohn, Donald B.

Affiliation

Carbonaro DA; Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital, Los Angeles, CA 90027, USA.

Blood ; 111(12): 5745-54, 2008 Jun 15.

Article in En | MEDLINE | ID: mdl-18356486

Subject(s)

Adenosine Deaminase/genetics; Bone Marrow Transplantation; Severe Combined Immunodeficiency/immunology; Severe Combined Immunodeficiency/therapy; T-Lymphocyte Subsets/immunology; Adenosine Deaminase/metabolism; Animals; Animals, Newborn; Enzyme Activation; Graft Survival/immunology; Interleukin Receptor Common gamma Subunit/genetics; Mice; Mice, Inbred Strains; Mice, Knockout; Mice, SCID; Recovery of Function/immunology; Severe Combined Immunodeficiency/genetics; Survival Rate; T-Lymphocyte Subsets/cytology; Transplantation Chimera; Transplantation Conditioning

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Deaminase / T-Lymphocyte Subsets / Bone Marrow Transplantation / Severe Combined Immunodeficiency Limits: Animals Language: En Journal: Blood Year: 2008 Type: Article Affiliation country: United States

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