A mutual prodrug ester of GABA and perphenazine exhibits antischizophrenic efficacy with diminished extrapyramidal effects.

Nudelman, Abraham; Gil-Ad, Irit; Shpaisman, Nava; Terasenko, Igor; Ron, Hanna; Savitsky, Kinneret; Geffen, Yona; Weizman, Abraham; Rephaeli, Ada

Nudelman, Abraham; Gil-Ad, Irit; Shpaisman, Nava; Terasenko, Igor; Ron, Hanna; Savitsky, Kinneret; Geffen, Yona; Weizman, Abraham; Rephaeli, Ada.

Affiliation

Nudelman A; Department of Chemistry, Bar Ilan University, Ramat Gan, Israel. adarep@post.tau.ac.il

J Med Chem ; 51(9): 2858-62, 2008 May 08.

Article in En | MEDLINE | ID: mdl-18363346

Subject(s)

Antipsychotic Agents/chemical synthesis; Dyskinesia, Drug-Induced/etiology; Perphenazine/analogs & derivatives; Perphenazine/chemical synthesis; Prodrugs/chemical synthesis; gamma-Aminobutyric Acid/analogs & derivatives; gamma-Aminobutyric Acid/chemical synthesis; Administration, Oral; Animals; Antipsychotic Agents/adverse effects; Antipsychotic Agents/pharmacology; Biological Availability; Catalepsy/chemically induced; Dextroamphetamine; Esters; Fluphenazine/adverse effects; Fluphenazine/analogs & derivatives; Fluphenazine/chemical synthesis; Fluphenazine/pharmacology; Male; Perphenazine/adverse effects; Perphenazine/pharmacology; Prodrugs/adverse effects; Prodrugs/pharmacology; Prolactin/metabolism; Rats; Rats, Wistar; Schizophrenia/drug therapy; gamma-Aminobutyric Acid/adverse effects; gamma-Aminobutyric Acid/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Perphenazine / Antipsychotic Agents / Prodrugs / Dyskinesia, Drug-Induced / Gamma-Aminobutyric Acid Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Type: Article Affiliation country: Israel

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