Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation.

Liu, Dingjiang; Ren, Da; Huang, Holly; Dankberg, Jane; Rosenfeld, Robert; Cocco, Melanie J; Li, Luke; Brems, David N; Remmele, Richard L

Liu, Dingjiang; Ren, Da; Huang, Holly; Dankberg, Jane; Rosenfeld, Robert; Cocco, Melanie J; Li, Luke; Brems, David N; Remmele, Richard L.

Affiliation

Liu D; Department of Pharmaceutics, Amgen, Inc., Thousand Oaks, California 91320, USA. liud@amgen.com

Biochemistry ; 47(18): 5088-100, 2008 May 06.

Article in En | MEDLINE | ID: mdl-18407665

Subject(s)

Immunoglobulin Fc Fragments/chemistry; Immunoglobulin Fc Fragments/immunology; Immunoglobulin G/chemistry; Immunoglobulin G/immunology; Amino Acid Sequence; Chromatography, High Pressure Liquid; Circular Dichroism; Humans; Immunoglobulin Fc Fragments/genetics; Immunoglobulin Fc Fragments/isolation & purification; Immunoglobulin G/genetics; Kinetics; Methionine/metabolism; Models, Molecular; Molecular Sequence Data; Mutation/genetics; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protein Denaturation; Protein Structure, Tertiary; Temperature

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin Fc Fragments Limits: Humans Language: En Journal: Biochemistry Year: 2008 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google