An in vitro mechanistic study to elucidate the desipramine/bupropion clinical drug-drug interaction.

Reese, Melinda J; Wurm, Robert M; Muir, Keith T; Generaux, Grant T; St John-Williams, Lisa; McConn, Donavon J

Reese, Melinda J; Wurm, Robert M; Muir, Keith T; Generaux, Grant T; St John-Williams, Lisa; McConn, Donavon J.

Affiliation

Reese MJ; Departments of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc., Room MAI.A227D, Research Triangle Park, NC 27709, USA. mindy.j.reese@gsk.com

Drug Metab Dispos ; 36(7): 1198-201, 2008 Jul.

Article in En | MEDLINE | ID: mdl-18420781

Subject(s)

Antidepressive Agents, Second-Generation/pharmacology; Antidepressive Agents, Tricyclic/pharmacology; Bupropion/pharmacology; Desipramine/pharmacology; Antidepressive Agents, Second-Generation/pharmacokinetics; Antidepressive Agents, Tricyclic/pharmacokinetics; Area Under Curve; Bupropion/pharmacokinetics; Cytochrome P-450 CYP2D6/metabolism; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine/pharmacokinetics; Drug Interactions; Enzyme Inhibitors/pharmacokinetics; Enzyme Inhibitors/pharmacology; Humans; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bupropion / Antidepressive Agents, Second-Generation / Desipramine / Antidepressive Agents, Tricyclic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2008 Type: Article Affiliation country: United States

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