Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.
IUBMB Life
; 60(6): 390-7, 2008 Jun.
Article
in En
| MEDLINE
| ID: mdl-18425793
ABSTRACT
Bcl-2 family members are the arbiters of mitochondrial apoptotic pathway, which is conserved through evolution. The stoichiometry of pro- versus antiapoptotic Bcl-2 family members in the cell determines whether the cell lives or dies. This fine balance is regulated at the transcriptional or posttranslational level in response to various cellular cues. These signals are transmitted through the upstream molecules in the pathway, that is, the BH3-only molecules that results in the activation of the adaptor molecules, Bax and Bak, at the mitochondrial surface ensuing mitochondrial dysfunction and apoptosis. Understanding the activation process offers a great potential in the therapeutic intervention of many diseases such as cancer and autoimmune disorders.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Apoptosis
/
Proto-Oncogene Proteins c-bcl-2
/
Mitochondria
Limits:
Animals
/
Humans
Language:
En
Journal:
IUBMB Life
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2008
Type:
Article
Affiliation country:
Australia