A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele.

Haasl, Ryan J; Ahmadi, M Reza; Meethal, Sivan Vadakkadath; Gleason, Carey E; Johnson, Sterling C; Asthana, Sanjay; Bowen, Richard L; Atwood, Craig S

Haasl, Ryan J; Ahmadi, M Reza; Meethal, Sivan Vadakkadath; Gleason, Carey E; Johnson, Sterling C; Asthana, Sanjay; Bowen, Richard L; Atwood, Craig S.

Affiliation

Haasl RJ; Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA. haasl@wisc.edu

BMC Med Genet ; 9: 37, 2008 Apr 25.

Article in En | MEDLINE | ID: mdl-18439297

Subject(s)

Alzheimer Disease/genetics; Apolipoprotein E4/genetics; Luteinizing Hormone, beta Subunit/genetics; Mutation, Missense; Receptors, LH/genetics; Age of Onset; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Chi-Square Distribution; Exons; Female; Humans; Introns; Linkage Disequilibrium; Male; Polymorphism, Genetic; Risk Factors; Sex Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, LH / Mutation, Missense / Luteinizing Hormone, beta Subunit / Apolipoprotein E4 / Alzheimer Disease Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: BMC Med Genet Journal subject: GENETICA MEDICA Year: 2008 Type: Article Affiliation country: United States

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