Inflammation and oxidant-stress in beta-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial.

Walter, Patrick B; Macklin, Eric A; Porter, John; Evans, Patricia; Kwiatkowski, Janet L; Neufeld, Ellis J; Coates, Thomas; Giardina, Patricia J; Vichinsky, Elliott; Olivieri, Nancy; Alberti, Daniele; Holland, Jaymes; Harmatz, Paul

Walter, Patrick B; Macklin, Eric A; Porter, John; Evans, Patricia; Kwiatkowski, Janet L; Neufeld, Ellis J; Coates, Thomas; Giardina, Patricia J; Vichinsky, Elliott; Olivieri, Nancy; Alberti, Daniele; Holland, Jaymes; Harmatz, Paul.

Affiliation

Walter PB; Children's Hospital & Research Center Oakland, 747 52nd Street, Oakland, CA 94609, USA.

Haematologica ; 93(6): 817-25, 2008 Jun.

Article in En | MEDLINE | ID: mdl-18469351

Subject(s)

Benzoates/pharmacology; Deferoxamine/pharmacology; Iron Chelating Agents/pharmacology; Oxidants/metabolism; Triazoles/pharmacology; beta-Thalassemia/drug therapy; Adolescent; Adult; Ascorbic Acid/metabolism; Benzoates/adverse effects; C-Reactive Protein/metabolism; Child; Deferasirox; Deferoxamine/adverse effects; Female; Humans; Iron Chelating Agents/adverse effects; Lipid Peroxidation; Male; Oxidative Stress; Triazoles/adverse effects; Vitamin E/metabolism; beta-Thalassemia/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Benzoates / Iron Chelating Agents / Oxidants / Beta-Thalassemia / Deferoxamine Type of study: Clinical_trials Limits: Adolescent / Adult / Child / Female / Humans / Male Language: En Journal: Haematologica Year: 2008 Type: Article Affiliation country: United States

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