A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential.

Heo, Jin-Chul; Son, Minsik; Woo, Sang-Uk; Kweon, Mi-Ae; Yoon, Eun Kyung; Lee, Hee Kyung; Choi, Won-Sik; Cho, Kang-Jin; Lee, Sang-Han

Heo, Jin-Chul; Son, Minsik; Woo, Sang-Uk; Kweon, Mi-Ae; Yoon, Eun Kyung; Lee, Hee Kyung; Choi, Won-Sik; Cho, Kang-Jin; Lee, Sang-Han.

Affiliation

Heo JC; Food and Bio-Industry Research Institute, Graduate School, Kyungpook National University, Daegu, Korea.

Oncol Rep ; 19(6): 1399-403, 2008 Jun.

Article in En | MEDLINE | ID: mdl-18497943

Subject(s)

Endothelium, Vascular/drug effects; Geum/chemistry; Melanoma, Experimental/blood supply; Methylene Chloride/pharmacology; Neovascularization, Pathologic/drug therapy; Animals; Blotting, Western; Cell Adhesion/drug effects; Cell Movement/drug effects; Cell Proliferation/drug effects; Cells, Cultured; Endothelium, Vascular/metabolism; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; Melanoma, Experimental/metabolism; Melanoma, Experimental/pathology; Mice; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/pathology; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Umbilical Veins/cytology; p38 Mitogen-Activated Protein Kinases/metabolism

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Endothelium, Vascular / Geum / Methylene Chloride / Neovascularization, Pathologic Limits: Animals / Humans Language: En Journal: Oncol Rep Journal subject: NEOPLASIAS Year: 2008 Type: Article

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