Molecular and neural mediators of leptin action.
Physiol Behav
; 94(5): 637-42, 2008 Aug 06.
Article
in En
| MEDLINE
| ID: mdl-18501391
ABSTRACT
The adipose tissue-derived hormone, leptin, acts via its receptor (LepRb) in the brain to regulate energy balance and neuroendocrine function. Parsing the biology of leptin requires understanding LepRb signaling and the roles for specific signaling pathways in neural and physiological leptin action. Since the leptin acts via a broadly distributed network of LepRb-expressing neurons, understanding the function of each of these LepRb neural populations will also be crucial. Here, we review the status of knowledge regarding the molecular mediators of leptin action and the neural substrate via which leptin acts to regulate physiologic processes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Leptin
/
Receptors, Leptin
/
Hypothalamus
/
Neurons
Limits:
Animals
/
Humans
Language:
En
Journal:
Physiol Behav
Year:
2008
Type:
Article
Affiliation country:
United States