Two independent ways of preparing hypercharged hydrolyzable polyaminorotaxane.
Biomacromolecules
; 9(7): 2007-13, 2008 Jul.
Article
in En
| MEDLINE
| ID: mdl-18517251
ABSTRACT
The aim of this work is to synthesize new PEO-based polyrotaxanes from modified cyclodextrins. Two strategies are discussed and compared. In the first, a pseudopolyrotaxane was formed between alpha,omega- PEO dimethacrylate and alpha-cyclodextrin. A coupling reaction between 1-pyrenebutyric acid N-hydroxysuccinimide ester was carried out to block the cyclic molecules onto the PEO. Cyclodextrins of the supramolecular assemblies were then oxidized using sodium periodate and reacted with spermine to form a potentially highly charged polyrotaxane. In the second strategy, cyclodextrins were first modified, and used to form the polyrotaxane through the pseudopolyrotaxane synthesis followed by the blocking reaction. Acidic titration allowed quantifying the number of amine functions borne by the supramolecular assemblies through two variables the number of rings per polymer chain and the number of spermine groups per cyclic molecule. The supramolecules obtained by both strategies are discussed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Poloxamer
/
Cyclodextrins
/
Rotaxanes
Language:
En
Journal:
Biomacromolecules
Journal subject:
BIOLOGIA MOLECULAR
Year:
2008
Type:
Article
Affiliation country:
France