MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival.

Jin, Hongkui; Yang, Renhui; Zheng, Zhong; Romero, Mally; Ross, Jed; Bou-Reslan, Hani; Carano, Richard A D; Kasman, Ian; Mai, Elaine; Young, Judy; Zha, Jiping; Zhang, Zemin; Ross, Sarajane; Schwall, Ralph; Colbern, Gail; Merchant, Mark

Jin, Hongkui; Yang, Renhui; Zheng, Zhong; Romero, Mally; Ross, Jed; Bou-Reslan, Hani; Carano, Richard A D; Kasman, Ian; Mai, Elaine; Young, Judy; Zha, Jiping; Zhang, Zemin; Ross, Sarajane; Schwall, Ralph; Colbern, Gail; Merchant, Mark.

Affiliation

Jin H; Department of Translational Oncology, Genentech, Inc., South San Francisco, California 94080, USA. hkj@gene.com

Cancer Res ; 68(11): 4360-8, 2008 Jun 01.

Article in En | MEDLINE | ID: mdl-18519697

Subject(s)

Adenocarcinoma/pathology; Antibodies, Monoclonal/immunology; Pancreatic Neoplasms/pathology; Receptor Protein-Tyrosine Kinases/immunology; Adenocarcinoma/metabolism; Animals; Cell Line, Tumor; Cell Proliferation; Female; Humans; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Nude; Neovascularization, Pathologic/immunology; Pancreatic Neoplasms/blood supply; Pancreatic Neoplasms/metabolism; Phosphorylation; Signal Transduction; Survival Analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Adenocarcinoma / Receptor Protein-Tyrosine Kinases / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2008 Type: Article Affiliation country: United States

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