Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.

Zhang, Mingzhu; Jovic, Florence; Vickers, Troy; Dyck, Brian; Tamiya, Junko; Grey, Jonathan; Tran, Joe A; Fleck, Beth A; Pick, Rebecca; Foster, Alan C; Chen, Chen

Zhang, Mingzhu; Jovic, Florence; Vickers, Troy; Dyck, Brian; Tamiya, Junko; Grey, Jonathan; Tran, Joe A; Fleck, Beth A; Pick, Rebecca; Foster, Alan C; Chen, Chen.

Affiliation

Zhang M; Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, CA 92130, USA.

Bioorg Med Chem Lett ; 18(13): 3682-6, 2008 Jul 01.

Article in En | MEDLINE | ID: mdl-18539031

Subject(s)

Bridged Bicyclo Compounds, Heterocyclic/chemistry; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Neurotransmitter Transport Proteins/chemistry; Animals; Caco-2 Cells; Chemistry, Pharmaceutical/methods; Drug Design; Humans; Inhibitory Concentration 50; Membrane Transport Proteins/chemistry; Membrane Transport Proteins/pharmacology; Models, Chemical; Neurotransmitter Agents/metabolism; Neurotransmitter Transport Proteins/antagonists & inhibitors; Norepinephrine/chemistry; Pain; Rats; Structure-Activity Relationship

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bridged Bicyclo Compounds, Heterocyclic / Neurotransmitter Transport Proteins Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google