Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment.
Allergy
; 63(7): 742-50, 2008 Jul.
Article
in En
| MEDLINE
| ID: mdl-18592619
ABSTRACT
BACKGROUND:
Long-term treatment for atopic dermatitis (AD) using low dose, intermittent, topical anti-inflammatory agents may control acute disease and prevent relapses. This 12-month, European, multicentre, randomized study investigated whether the proactive use of 0.1% tacrolimus ointment applied twice weekly can keep AD in remission and reduce the incidence of disease exacerbations (DE).METHODS:
During the initial open-label period, 257 adults with AD applied 0.1% tacrolimus ointment twice daily (b.i.d.) for up to 6 weeks to affected areas. When an Investigator Global Assessment (IGA) score ofRESULTS:
Proactive tacrolimus 0.1% ointment application significantly reduced the number of DEs requiring substantial therapeutic intervention (median difference 2; P < 0.001; Wilcoxon rank sum test), the percentage of DE treatment days (median difference 15.2%; P < 0.001; Wilcoxon rank sum test) and increased the time to first DE (median 142 vs 15 days; P < 0.001; stratified log-rank test). The adverse event profile was similar for the two treatment approaches.CONCLUSION:
A 12-month, twice weekly proactive tacrolimus ointment application was an effective treatment in most study patients which prevented, delayed and reduced the occurrence of AD exacerbations
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tacrolimus
/
Dermatitis, Atopic
/
Immunosuppressive Agents
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Allergy
Year:
2008
Type:
Article
Affiliation country:
Germany