Successful kinase bypass with new acyclovir phosphoramidate prodrugs.

McGuigan, Christopher; Derudas, Marco; Bugert, Joachim J; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan

McGuigan, Christopher; Derudas, Marco; Bugert, Joachim J; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan.

Affiliation

McGuigan C; Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK. mcguigan@cardiff.ac.uk

Bioorg Med Chem Lett ; 18(15): 4364-7, 2008 Aug 01.

Article in En | MEDLINE | ID: mdl-18614365

Subject(s)

Acyclovir; Amides; Antiviral Agents; Phosphoric Acids; Prodrugs; Thymidine Kinase/metabolism; Acyclovir/analogs & derivatives; Acyclovir/chemical synthesis; Acyclovir/chemistry; Acyclovir/pharmacology; Acyclovir/therapeutic use; Amides/chemical synthesis; Amides/chemistry; Amides/pharmacology; Amides/therapeutic use; Antiviral Agents/chemical synthesis; Antiviral Agents/chemistry; Antiviral Agents/pharmacology; Antiviral Agents/therapeutic use; Herpesvirus 1, Human/drug effects; Herpesvirus 2, Human/drug effects; Herpesvirus 3, Human; Humans; Molecular Structure; Phosphoric Acids/chemical synthesis; Phosphoric Acids/chemistry; Phosphoric Acids/pharmacology; Phosphoric Acids/therapeutic use; Prodrugs/chemical synthesis; Prodrugs/chemistry; Prodrugs/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Phosphoric Acids / Thymidine Kinase / Acyclovir / Prodrugs / Amides Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United kingdom

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