Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.

Hoffman, Hal M; Throne, Martin L; Amar, N J; Sebai, Mohamed; Kivitz, Alan J; Kavanaugh, Arthur; Weinstein, Steven P; Belomestnov, Pavel; Yancopoulos, George D; Stahl, Neil; Mellis, Scott J

Hoffman, Hal M; Throne, Martin L; Amar, N J; Sebai, Mohamed; Kivitz, Alan J; Kavanaugh, Arthur; Weinstein, Steven P; Belomestnov, Pavel; Yancopoulos, George D; Stahl, Neil; Mellis, Scott J.

Affiliation

Hoffman HM; Division of Rheumatology and Allergy/Immunology, University of California at San Diego, La Jolla, CA 92093-0635, USA. hahoffman@popmail.ucsd.edu

Arthritis Rheum ; 58(8): 2443-52, 2008 Aug.

Article in En | MEDLINE | ID: mdl-18668535

Subject(s)

Arthralgia/drug therapy; Arthralgia/genetics; Carrier Proteins/genetics; Familial Mediterranean Fever/drug therapy; Familial Mediterranean Fever/genetics; Immunoglobulin Fc Fragments/therapeutic use; Recombinant Fusion Proteins/therapeutic use; Adult; Aged; Arthralgia/blood; C-Reactive Protein/metabolism; Double-Blind Method; Familial Mediterranean Fever/blood; Female; Humans; Immunoglobulin Fc Fragments/administration & dosage; Immunoglobulin Fc Fragments/adverse effects; Injections, Subcutaneous; Male; Middle Aged; Mutation/genetics; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, Interleukin-1/antagonists & inhibitors; Recombinant Fusion Proteins/administration & dosage; Recombinant Fusion Proteins/adverse effects; Serum Amyloid A Protein/metabolism; Single-Blind Method; Syndrome; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Familial Mediterranean Fever / Recombinant Fusion Proteins / Immunoglobulin Fc Fragments / Carrier Proteins / Arthralgia Type of study: Clinical_trials / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Arthritis Rheum Year: 2008 Type: Article Affiliation country: United States

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