Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.

Osei-Hyiaman, Douglas; Liu, Jie; Zhou, Liang; Godlewski, Grzegorz; Harvey-White, Judith; Jeong, Won-il; Bátkai, Sándor; Marsicano, Giovanni; Lutz, Beat; Buettner, Christoph; Kunos, George

Osei-Hyiaman, Douglas; Liu, Jie; Zhou, Liang; Godlewski, Grzegorz; Harvey-White, Judith; Jeong, Won-il; Bátkai, Sándor; Marsicano, Giovanni; Lutz, Beat; Buettner, Christoph; Kunos, George.

Affiliation

Osei-Hyiaman D; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.

J Clin Invest ; 118(9): 3160-9, 2008 Sep.

Article in En | MEDLINE | ID: mdl-18677409

Subject(s)

Animal Feed; Dyslipidemias/metabolism; Fatty Liver/metabolism; Insulin/metabolism; Leptin/metabolism; Liver/metabolism; Receptor, Cannabinoid, CB1/metabolism; Animals; Dyslipidemias/genetics; Fatty Liver/genetics; Female; Insulin/genetics; Insulin Resistance/genetics; Leptin/genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity/complications; Receptor, Cannabinoid, CB1/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leptin / Receptor, Cannabinoid, CB1 / Dyslipidemias / Fatty Liver / Insulin / Liver / Animal Feed Limits: Animals Language: En Journal: J Clin Invest Year: 2008 Type: Article Affiliation country: United States

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