The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke.

Elkind, Mitchell S V; Sacco, Ralph L; MacArthur, Robert B; Fink, Daniel J; Peerschke, Ellinor; Andrews, Howard; Neils, Greg; Stillman, Josh; Corporan, Tania; Leifer, Dana; Cheung, Ken

Elkind, Mitchell S V; Sacco, Ralph L; MacArthur, Robert B; Fink, Daniel J; Peerschke, Ellinor; Andrews, Howard; Neils, Greg; Stillman, Josh; Corporan, Tania; Leifer, Dana; Cheung, Ken.

Affiliation

Elkind MS; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. mse13@columbia.edu

Int J Stroke ; 3(3): 210-8, 2008 Aug.

Article in En | MEDLINE | ID: mdl-18705902

Subject(s)

Brain Ischemia/prevention & control; Lovastatin/toxicity; Stroke/prevention & control; Acute Disease; Animals; Brain Ischemia/drug therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Hydroxymethylglutaryl-CoA Reductase Inhibitors/toxicity; Lovastatin/pharmacokinetics; Lovastatin/therapeutic use; Research Design; Safety; Stroke/drug therapy; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lovastatin / Brain Ischemia / Stroke Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Int J Stroke Year: 2008 Type: Article Affiliation country: United States

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