Frequent reduction or absence of detection of the JAK2-mutated clone in JAK2V617F-positive patients within the first years of hydroxyurea therapy.

Girodon, François; Schaeffer, Céline; Cleyrat, Cédric; Mounier, Morgane; Lafont, Ingrid; Santos, Frédéric Dos; Duval, Aurélie; Vidal, Aurélie; Maynadié, Marc; Hermouet, Sylvie

Girodon, François; Schaeffer, Céline; Cleyrat, Cédric; Mounier, Morgane; Lafont, Ingrid; Santos, Frédéric Dos; Duval, Aurélie; Vidal, Aurélie; Maynadié, Marc; Hermouet, Sylvie.

Affiliation

Girodon F; Laboratoire d'Hématologie, Hôpital du Bocage, CHU de Dijon, Dijon, France. francois.girodon@chu-dijon

Haematologica ; 93(11): 1723-7, 2008 Nov.

Article in En | MEDLINE | ID: mdl-18728027

Subject(s)

Hydroxyurea/therapeutic use; Janus Kinase 2/genetics; Polycythemia Vera/drug therapy; Thrombocythemia, Essential/drug therapy; Aged; Aged, 80 and over; Amino Acid Substitution; Antisickling Agents/therapeutic use; Cohort Studies; DNA Primers; Female; Granulocytes/physiology; Humans; Janus Kinase 2/blood; Janus Kinase 2/deficiency; Male; Middle Aged; Mutation; Polycythemia Vera/genetics; Retrospective Studies; Thrombocythemia, Essential/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycythemia Vera / Janus Kinase 2 / Thrombocythemia, Essential / Hydroxyurea Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Haematologica Year: 2008 Type: Article Affiliation country: France

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