Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity.

Valli, Claudia; Paroni, Gabriela; Di Francesco, Angela Maria; Riccardi, Riccardo; Tavecchio, Michele; Erba, Eugenio; Boldetti, Andrea; Gianni', Maurizio; Fratelli, Maddalena; Pisano, Claudio; Merlini, Lucio; Antoccia, Antonio; Cenciarelli, Chiara; Terao, Mineko; Garattini, Enrico

Valli, Claudia; Paroni, Gabriela; Di Francesco, Angela Maria; Riccardi, Riccardo; Tavecchio, Michele; Erba, Eugenio; Boldetti, Andrea; Gianni', Maurizio; Fratelli, Maddalena; Pisano, Claudio; Merlini, Lucio; Antoccia, Antonio; Cenciarelli, Chiara; Terao, Mineko; Garattini, Enrico.

Affiliation

Valli C; Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20157 Milan, Italy.

Mol Cancer Ther ; 7(9): 2941-54, 2008 Sep.

Article in En | MEDLINE | ID: mdl-18790775

Subject(s)

Adamantane/analogs & derivatives; Cinnamates/pharmacology; DNA Breaks, Double-Stranded/drug effects; Retinoids/pharmacology; S Phase/drug effects; Adamantane/pharmacology; Animals; CHO Cells; Cell Death/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Chromosome Aberrations/drug effects; Cricetinae; Cricetulus; DNA Repair/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation/drug effects; Histones/metabolism; Humans; Phosphorylation/drug effects; Protein Kinases/metabolism; Recombination, Genetic/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinoids / Adamantane / S Phase / Cinnamates / DNA Breaks, Double-Stranded Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2008 Type: Article Affiliation country: Italy

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