Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

Wang, Zhong; Smith, Kevin S; Murphy, Mark; Piloto, Obdulio; Somervaille, Tim C P; Cleary, Michael L

Wang, Zhong; Smith, Kevin S; Murphy, Mark; Piloto, Obdulio; Somervaille, Tim C P; Cleary, Michael L.

Affiliation

Wang Z; Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature ; 455(7217): 1205-9, 2008 Oct 30.

Article in En | MEDLINE | ID: mdl-18806775

Subject(s)

Cell Transformation, Neoplastic; Glycogen Synthase Kinase 3/metabolism; Leukemia, Lymphoid/drug therapy; Leukemia, Lymphoid/pathology; Myeloid-Lymphoid Leukemia Protein/metabolism; Animals; Cell Division; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; G1 Phase; Glycogen Synthase Kinase 3/antagonists & inhibitors; Glycogen Synthase Kinase 3/deficiency; Glycogen Synthase Kinase 3/genetics; Histone-Lysine N-Methyltransferase; Humans; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Intracellular Signaling Peptides and Proteins/metabolism; Isoenzymes/metabolism; Leukemia, Lymphoid/enzymology; Leukemia, Lymphoid/metabolism; Mice; Mice, Inbred C57BL; Mice, SCID; Myeloid Progenitor Cells/enzymology; Myeloid Progenitor Cells/metabolism; Myeloid Progenitor Cells/pathology; Precursor Cells, B-Lymphoid/enzymology; Precursor Cells, B-Lymphoid/metabolism; Precursor Cells, B-Lymphoid/pathology; Proto-Oncogene Mas

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Lymphoid / Cell Transformation, Neoplastic / Glycogen Synthase Kinase 3 / Myeloid-Lymphoid Leukemia Protein Limits: Animals / Humans Language: En Journal: Nature Year: 2008 Type: Article Affiliation country: United States

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