Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease.

van Roon-Mom, Willeke M C; Pepers, Barry A; 't Hoen, Peter A C; Verwijmeren, Carola A C M; den Dunnen, Johan T; Dorsman, Josephine C; van Ommen, Gertjan B

van Roon-Mom, Willeke M C; Pepers, Barry A; 't Hoen, Peter A C; Verwijmeren, Carola A C M; den Dunnen, Johan T; Dorsman, Josephine C; van Ommen, Gertjan B.

Affiliation

van Roon-Mom WM; Center for Human and Clinical Genetics, Leiden, the Netherlands. w.vanroon@lumc.nl

BMC Mol Biol ; 9: 84, 2008 Oct 09.

Article in En | MEDLINE | ID: mdl-18844975

Subject(s)

Dopamine/biosynthesis; Huntington Disease/genetics; Mutation; NF-E2-Related Factor 2/metabolism; Nerve Tissue Proteins/genetics; Nuclear Proteins/genetics; Animals; Disease Models, Animal; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Huntingtin Protein; Huntington Disease/metabolism; NF-E2-Related Factor 2/genetics; Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Oxidative Stress; PC12 Cells; RNA, Messenger/metabolism; Rats; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Dopamine / Huntington Disease / NF-E2-Related Factor 2 / Mutation / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: BMC Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2008 Type: Article Affiliation country: Netherlands

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