The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.

Godlewski, Grzegorz; Offertáler, László; Osei-Hyiaman, Douglas; Mo, Fong Ming; Harvey-White, Judith; Liu, Jie; Davis, Margaret I; Zhang, Li; Razdan, Raj K; Milman, Garry; Pacher, Pal; Mukhopadhyay, Partha; Lovinger, David M; Kunos, George

Godlewski, Grzegorz; Offertáler, László; Osei-Hyiaman, Douglas; Mo, Fong Ming; Harvey-White, Judith; Liu, Jie; Davis, Margaret I; Zhang, Li; Razdan, Raj K; Milman, Garry; Pacher, Pal; Mukhopadhyay, Partha; Lovinger, David M; Kunos, George.

Affiliation

Godlewski G; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892-9413, USA. godlewskig@mail.nih.gov

J Pharmacol Exp Ther ; 328(1): 351-61, 2009 Jan.

Article in En | MEDLINE | ID: mdl-18923087

Subject(s)

Arachidonic Acids/physiology; Brain/physiology; Large-Conductance Calcium-Activated Potassium Channels/physiology; Serine/analogs & derivatives; Alternative Splicing; Animals; Cell Line; Genetic Variation; Humans; Kidney/enzymology; Large-Conductance Calcium-Activated Potassium Channels/genetics; Male; Membrane Potentials/physiology; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Serine/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Brain / Arachidonic Acids / Large-Conductance Calcium-Activated Potassium Channels Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2009 Type: Article Affiliation country: United States

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