Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Mullins, Eric S; Kombrinck, Keith W; Talmage, Kathryn E; Shaw, Maureen A; Witte, David P; Ullman, Joni M; Degen, Sandra J; Sun, William; Flick, Matthew J; Degen, Jay L

Mullins, Eric S; Kombrinck, Keith W; Talmage, Kathryn E; Shaw, Maureen A; Witte, David P; Ullman, Joni M; Degen, Sandra J; Sun, William; Flick, Matthew J; Degen, Jay L.

Affiliation

Mullins ES; Division of Pediatric Hematology/Oncology, Cincinnati Children's Hospital Research Foundation and University of Cincinnati College of Medicine, OH 45229-3039, USA.

Blood ; 113(3): 696-704, 2009 Jan 15.

Article in En | MEDLINE | ID: mdl-18927430

Subject(s)

Brain/pathology; Hemorrhage/genetics; Myocardium/pathology; Prothrombin/metabolism; Animals; Blood Coagulation/genetics; Blotting, Northern; Inflammation/genetics; Integrases/genetics; Mice; Mice, Knockout; Peritonitis/genetics; Prothrombin/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Prothrombin / Hemorrhage / Myocardium Limits: Animals Language: En Journal: Blood Year: 2009 Type: Article Affiliation country: United States

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