Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans.

Evans, Eric A; Kawli, Trupti; Tan, Man-Wah

Evans, Eric A; Kawli, Trupti; Tan, Man-Wah.

Affiliation

Evans EA; Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.

PLoS Pathog ; 4(10): e1000175, 2008 Oct.

Article in En | MEDLINE | ID: mdl-18927620

Subject(s)

Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Caenorhabditis elegans/immunology; Immune Tolerance/genetics; Pseudomonas aeruginosa/physiology; Receptor, Insulin/genetics; Animals; Caenorhabditis elegans/microbiology; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans Proteins/physiology; Down-Regulation/genetics; Down-Regulation/immunology; Forkhead Transcription Factors; Host-Pathogen Interactions/genetics; Host-Pathogen Interactions/immunology; Immunity, Innate/genetics; Insulin/metabolism; Models, Biological; Pseudomonas Infections/genetics; Pseudomonas Infections/immunology; Pseudomonas aeruginosa/pathogenicity; Receptor, Insulin/metabolism; Signal Transduction/genetics; Signal Transduction/immunology; Transcription Factors/physiology; Virulence Factors/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Receptor, Insulin / Caenorhabditis elegans / Caenorhabditis elegans Proteins / Immune Tolerance Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS Pathog Year: 2008 Type: Article Affiliation country: United States

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