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Can NK cells be a therapeutic target in human cancer?
Chan, Christopher J; Andrews, Daniel M; Smyth, Mark J.
Affiliation
  • Chan CJ; Peter MacCallum Cancer Centre, East Melbourne, Australia.
Eur J Immunol ; 38(11): 2964-8, 2008 Nov.
Article in En | MEDLINE | ID: mdl-18979512
ABSTRACT
Our current knowledge of NK-cell recognition and effector function suggests that it will be possible to design various new NK-cell-based immunotherapies against human cancer. The application of NK cells is already showing promise using HLA-mismatched haematopoietic stem cell transplantation for treatment of haematological malignancies. A better understanding of NK-cell heterogeneity and function will only broaden the applications for human cancer. Here we review the key developments that will propel this field.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Neoplasms Limits: Animals / Humans Language: En Journal: Eur J Immunol Year: 2008 Type: Article Affiliation country: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Neoplasms Limits: Animals / Humans Language: En Journal: Eur J Immunol Year: 2008 Type: Article Affiliation country: Australia