Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.

Montgomery, Justin I; Toogood, Peter L; Hutchings, Kim M; Liu, Jia; Narasimhan, Lakshmi; Braden, Timothy; Dermyer, Michael R; Kulynych, Angela D; Smith, Yvonne D; Warmus, Joseph S; Taylor, Clarke

Montgomery, Justin I; Toogood, Peter L; Hutchings, Kim M; Liu, Jia; Narasimhan, Lakshmi; Braden, Timothy; Dermyer, Michael R; Kulynych, Angela D; Smith, Yvonne D; Warmus, Joseph S; Taylor, Clarke.

Affiliation

Montgomery JI; Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor Campus, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. justin.montgomery@pfizer.com

Bioorg Med Chem Lett ; 19(3): 665-9, 2009 Feb 01.

Article in En | MEDLINE | ID: mdl-19121937

Subject(s)

Bacteria/enzymology; Chemistry, Pharmaceutical/methods; Phenyl Ethers/chemistry; Phenylalanine-tRNA Ligase/chemistry; Adenosine Triphosphate/chemistry; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Anti-Infective Agents/chemistry; Anti-Infective Agents/pharmacology; Drug Design; Drug Evaluation, Preclinical/methods; Inhibitory Concentration 50; Models, Chemical; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenyl Ethers / Phenylalanine-tRNA Ligase / Bacteria / Chemistry, Pharmaceutical Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

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