Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

Imaeda, Avlin B; Watanabe, Azuma; Sohail, Muhammad A; Mahmood, Shamail; Mohamadnejad, Mehdi; Sutterwala, Fayyaz S; Flavell, Richard A; Mehal, Wajahat Z

Imaeda, Avlin B; Watanabe, Azuma; Sohail, Muhammad A; Mahmood, Shamail; Mohamadnejad, Mehdi; Sutterwala, Fayyaz S; Flavell, Richard A; Mehal, Wajahat Z.

Affiliation

Imaeda AB; Section of Digestive Diseases, Yale University, New Haven, Connecticut 06520-8019, USA.

J Clin Invest ; 119(2): 305-14, 2009 Feb.

Article in En | MEDLINE | ID: mdl-19164858

Subject(s)

Acetaminophen/toxicity; Analgesics, Non-Narcotic/toxicity; Carrier Proteins/physiology; Liver/drug effects; Toll-Like Receptor 9/physiology; Animals; Apoptosis/drug effects; Aspirin/pharmacology; Caspase Inhibitors; Cell Line; Cyclooxygenase Inhibitors/pharmacology; Dose-Response Relationship, Drug; Humans; Immunity, Innate; Inflammation/chemically induced; Interleukin-18/biosynthesis; Interleukin-1beta/biosynthesis; Liver/pathology; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Analgesics, Non-Narcotic / Toll-Like Receptor 9 / Liver / Acetaminophen Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2009 Type: Article Affiliation country: United States

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