The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

Tan, E Y; Yan, M; Campo, L; Han, C; Takano, E; Turley, H; Candiloro, I; Pezzella, F; Gatter, K C; Millar, E K A; O'Toole, S A; McNeil, C M; Crea, P; Segara, D; Sutherland, R L; Harris, A L; Fox, S B

Tan, E Y; Yan, M; Campo, L; Han, C; Takano, E; Turley, H; Candiloro, I; Pezzella, F; Gatter, K C; Millar, E K A; O'Toole, S A; McNeil, C M; Crea, P; Segara, D; Sutherland, R L; Harris, A L; Fox, S B.

Affiliation

Tan EY; Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK.

Br J Cancer ; 100(2): 405-11, 2009 Jan 27.

Article in En | MEDLINE | ID: mdl-19165203

Subject(s)

Antigens, Neoplasm/metabolism; Antineoplastic Agents/therapeutic use; Biomarkers, Tumor/metabolism; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Carbonic Anhydrases/metabolism; Drug Resistance, Neoplasm; Adult; Aged; Aged, 80 and over; Breast Neoplasms/pathology; Carbonic Anhydrase IX; Dioxygenases/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Homeodomain Proteins/metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Hypoxia-Inducible Factor-Proline Dioxygenases; Immunoenzyme Techniques; Middle Aged; Mixed Function Oxygenases; Neoplasm Invasiveness; Neoplasm Staging; Procollagen-Proline Dioxygenase/metabolism; Prognosis; Repressor Proteins/metabolism; Survival Rate; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Biomarkers, Tumor / Carbonic Anhydrases / Drug Resistance, Neoplasm / Antigens, Neoplasm / Antineoplastic Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Humans / Middle aged Language: En Journal: Br J Cancer Year: 2009 Type: Article Affiliation country: United kingdom

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