Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Zhang, Rui; Deangelis, Alan; Wang, Aihua; Sieber-McMaster, Ellen; Li, Xun; Russell, Ronald; Pelton, Patricia; Xu, Jun; Zhu, Peifang; Zhou, Lubing; Demarest, Keith; Murray, William V; Kuo, Gee-Hong

Zhang, Rui; Deangelis, Alan; Wang, Aihua; Sieber-McMaster, Ellen; Li, Xun; Russell, Ronald; Pelton, Patricia; Xu, Jun; Zhu, Peifang; Zhou, Lubing; Demarest, Keith; Murray, William V; Kuo, Gee-Hong.

Affiliation

Zhang R; Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 8 Clarke Drive, Cranbury, NJ 08512, USA. rzhang4@prdus.jnj.com

Bioorg Med Chem Lett ; 19(4): 1101-4, 2009 Feb 15.

Article in En | MEDLINE | ID: mdl-19168353

Subject(s)

Glycolates/chemical synthesis; Glycolates/pharmacology; PPAR delta/agonists; Combinatorial Chemistry Techniques; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; Glycolates/chemistry; Humans; Models, Molecular; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Thiazoles/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: PPAR delta / Glycolates Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

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