Pentobarbital produces activation and block of {alpha}1{beta}2{gamma}2S GABAA receptors in rapidly perfused whole cells and membrane patches: divergent results can be explained by pharmacokinetics.

Gingrich, Kevin J; Burkat, Paul M; Roberts, William A

Gingrich, Kevin J; Burkat, Paul M; Roberts, William A.

Affiliation

Gingrich KJ; Department of Anesthesiology, New York University Langone Medical Center, New York, NY 10016, USA. kevin.gingrich@med.nyu.edu

J Gen Physiol ; 133(2): 171-88, 2009 Feb.

Article in En | MEDLINE | ID: mdl-19171770

Subject(s)

Pentobarbital/pharmacology; Receptors, GABA-A/drug effects; Receptors, GABA-A/metabolism; Animals; Binding Sites; Cell Compartmentation; Dose-Response Relationship, Drug; Feedback, Physiological/drug effects; GABA Modulators/pharmacology; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Intracellular Space/drug effects; Intracellular Space/metabolism; Ion Channel Gating/drug effects; Ion Channel Gating/physiology; Ion Transport/drug effects; Models, Biological; Patch-Clamp Techniques; Pharmacokinetics; Protein Subunits/drug effects; Protein Subunits/metabolism; Rats; Research Design; gamma-Aminobutyric Acid/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pentobarbital / Receptors, GABA-A Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Gen Physiol Year: 2009 Type: Article Affiliation country: United States

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