Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants.

Mustapha, Mirna; Fang, Qing; Gong, Tzy-Wen; Dolan, David F; Raphael, Yehoash; Camper, Sally A; Duncan, R Keith

Mustapha, Mirna; Fang, Qing; Gong, Tzy-Wen; Dolan, David F; Raphael, Yehoash; Camper, Sally A; Duncan, R Keith.

Affiliation

Mustapha M; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA.

J Neurosci ; 29(4): 1212-23, 2009 Jan 28.

Article in En | MEDLINE | ID: mdl-19176829

Subject(s)

Deafness/etiology; Gene Expression Regulation/genetics; Hypothyroidism/complications; KCNQ Potassium Channels/metabolism; Potassium Channels, Inwardly Rectifying/metabolism; Transcription Factor Pit-1/genetics; Age Factors; Animals; Animals, Newborn; Deafness/genetics; Deafness/pathology; Disease Models, Animal; Hair Cells, Auditory, Outer/diagnostic imaging; Hair Cells, Auditory, Outer/metabolism; Hair Cells, Auditory, Outer/pathology; Hair Cells, Auditory, Outer/ultrastructure; Hypothyroidism/genetics; KCNQ Potassium Channels/genetics; Mice; Mice, Mutant Strains; Microscopy, Electron, Transmission/methods; Molecular Motor Proteins/genetics; Molecular Motor Proteins/metabolism; Otoacoustic Emissions, Spontaneous/genetics; Potassium Channels, Inwardly Rectifying/genetics; Stria Vascularis/pathology; Synaptophysin/genetics; Synaptophysin/metabolism; Tectorial Membrane/pathology; Tectorial Membrane/ultrastructure; Ultrasonography

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Potassium Channels, Inwardly Rectifying / Deafness / KCNQ Potassium Channels / Transcription Factor Pit-1 / Hypothyroidism Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Year: 2009 Type: Article Affiliation country: United States

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