Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.

Chiang, Annette N; Valderramos, Juan-Carlos; Balachandran, Raghavan; Chovatiya, Raj J; Mead, Brian P; Schneider, Corinne; Bell, Samantha L; Klein, Michael G; Huryn, Donna M; Chen, Xiaojiang S; Day, Billy W; Fidock, David A; Wipf, Peter; Brodsky, Jeffrey L

Chiang, Annette N; Valderramos, Juan-Carlos; Balachandran, Raghavan; Chovatiya, Raj J; Mead, Brian P; Schneider, Corinne; Bell, Samantha L; Klein, Michael G; Huryn, Donna M; Chen, Xiaojiang S; Day, Billy W; Fidock, David A; Wipf, Peter; Brodsky, Jeffrey L.

Affiliation

Chiang AN; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Bioorg Med Chem ; 17(4): 1527-33, 2009 Feb 15.

Article in En | MEDLINE | ID: mdl-19195901

Subject(s)

Antimalarials/pharmacology; HSP70 Heat-Shock Proteins/antagonists & inhibitors; Plasmodium falciparum/drug effects; Pyrimidinones/pharmacology; Adenosine Triphosphatases/antagonists & inhibitors; Adenosine Triphosphatases/metabolism; Amides/pharmacology; Animals; Erythrocytes/parasitology; HSP70 Heat-Shock Proteins/metabolism; Humans; Malaria, Falciparum/drug therapy; Malaria, Falciparum/parasitology; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Pyrimidinones / HSP70 Heat-Shock Proteins / Antimalarials Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

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