Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.

Huang, Chiung-Chun; Liang, Ying-Ching; Lee, Cheng-Che; Wu, Mei-Ying; Hsu, Kuei-Sen

Huang, Chiung-Chun; Liang, Ying-Ching; Lee, Cheng-Che; Wu, Mei-Ying; Hsu, Kuei-Sen.

Affiliation

Huang CC; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Neuropsychopharmacology ; 34(8): 1979-92, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19212317

Subject(s)

Cocaine-Related Disorders/metabolism; Cocaine/pharmacology; Prefrontal Cortex/drug effects; Serotonin 5-HT2 Receptor Antagonists; Serotonin/metabolism; Substance Withdrawal Syndrome/metabolism; Animals; Cocaine-Related Disorders/physiopathology; Disease Models, Animal; Dopamine Uptake Inhibitors/pharmacology; Drug Administration Schedule; Drug Interactions/physiology; Excitatory Postsynaptic Potentials/drug effects; Excitatory Postsynaptic Potentials/physiology; GTP-Binding Proteins/drug effects; GTP-Binding Proteins/metabolism; Glutamic Acid/metabolism; Male; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex/metabolism; Pyramidal Cells/drug effects; Pyramidal Cells/metabolism; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A/metabolism; Serotonin Antagonists/pharmacology; Substance Withdrawal Syndrome/physiopathology; Synaptic Transmission/drug effects; Synaptic Transmission/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Substance Withdrawal Syndrome / Serotonin / Prefrontal Cortex / Cocaine / Cocaine-Related Disorders / Serotonin 5-HT2 Receptor Antagonists Limits: Animals Language: En Journal: Neuropsychopharmacology Journal subject: NEUROLOGIA / PSICOFARMACOLOGIA Year: 2009 Type: Article Affiliation country: Taiwan

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