Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway.

van Dop, Willemijn A; Uhmann, Anja; Wijgerde, Mark; Sleddens-Linkels, Esther; Heijmans, Jarom; Offerhaus, G Johan; van den Bergh Weerman, Marius A; Boeckxstaens, Guy E; Hommes, Daan W; Hardwick, James C; Hahn, Heidi; van den Brink, Gijs R

van Dop, Willemijn A; Uhmann, Anja; Wijgerde, Mark; Sleddens-Linkels, Esther; Heijmans, Jarom; Offerhaus, G Johan; van den Bergh Weerman, Marius A; Boeckxstaens, Guy E; Hommes, Daan W; Hardwick, James C; Hahn, Heidi; van den Brink, Gijs R.

Affiliation

van Dop WA; Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands. w.a.vandop@amc.uva.nl

Gastroenterology ; 136(7): 2195-2203.e1-7, 2009 Jun.

Article in En | MEDLINE | ID: mdl-19272384

Subject(s)

Cell Proliferation; Colon/pathology; Hedgehog Proteins/metabolism; Intestinal Mucosa/pathology; Signal Transduction/physiology; Animals; Bone Morphogenetic Proteins/genetics; Bone Morphogenetic Proteins/metabolism; Cells, Cultured; Colon/cytology; Colon/metabolism; Epithelial Cells/cytology; Epithelial Cells/physiology; Gene Expression Regulation, Developmental; Hedgehog Proteins/genetics; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa/cytology; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Models, Animal; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Signal Transduction/genetics; Wnt Proteins/genetics; Wnt Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Colon / Cell Proliferation / Hedgehog Proteins / Intestinal Mucosa Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Gastroenterology Year: 2009 Type: Article Affiliation country: Netherlands

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