Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints.

Tao, Yungan; Leteur, Céline; Yang, Ceyao; Zhang, Ping; Castedo, Maria; Pierré, Alain; Golsteyn, Roy M; Bourhis, Jean; Kroemer, Guido; Deutsch, Eric

Tao, Yungan; Leteur, Céline; Yang, Ceyao; Zhang, Ping; Castedo, Maria; Pierré, Alain; Golsteyn, Roy M; Bourhis, Jean; Kroemer, Guido; Deutsch, Eric.

Affiliation

Tao Y; UPRES EA27-10 Laboratoire Radiosensibilité des Tumeurs et Tissus Sains, University Paris-Sud XI Kremlin-Bicêtre and Institut Gustave-Roussy, 39 rue Camille-Desmoulins,Villejuif, France.

Cell Cycle ; 8(8): 1196-205, 2009 Apr 15.

Article in En | MEDLINE | ID: mdl-19305158

Subject(s)

Cell Cycle/drug effects; Protein Kinases/metabolism; Radiation-Sensitizing Agents/pharmacology; Tumor Suppressor Protein p53/metabolism; 14-3-3 Proteins/metabolism; Animals; Calcium-Binding Proteins/metabolism; Cell Cycle/radiation effects; Cell Cycle Proteins/metabolism; Cell Survival/drug effects; Cell Survival/radiation effects; Checkpoint Kinase 1; DNA Damage; Enzyme Activation/drug effects; Enzyme Activation/radiation effects; Flow Cytometry; G2 Phase/drug effects; G2 Phase/radiation effects; HCT116 Cells; Humans; Immunohistochemistry; Mad2 Proteins; Mice; Mitotic Index; Polyploidy; Quinolines/pharmacology; Quinuclidines/pharmacology; Radiation, Ionizing; Repressor Proteins/metabolism; Spindle Apparatus/drug effects; Spindle Apparatus/radiation effects; Tumor Stem Cell Assay

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Radiation-Sensitizing Agents / Cell Cycle / Tumor Suppressor Protein p53 Limits: Animals / Humans Language: En Journal: Cell Cycle Year: 2009 Type: Article Affiliation country: France

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