Homogeneous time-resolved fluoroimmunoassay for the measurement of midregional proadrenomedullin in plasma on the fully automated system B.R.A.H.M.S KRYPTOR.

ABSTRACT

OBJECTIVES: Evaluate the first automated assay measuring a mid regional fragment of the proadrenomedullin (MR-proADM). DESIGN AND METHODS: B.R.A.H.M.S MR-proADM KRYPTOR is a homogeneous assay. RESULTS: In 144 healthy individuals, MR-proADM mean (SD) was measured at 0.37 nmol/L (0.09). High correlation with the manual assay, B.R.A.H.M.S MR-proADM LIA, was found on 281 samples from patients suffering from community acquired pneumonia (correlation coefficient 0.97). CONCLUSIONS: This fast assay can be used in low respiratory tract infections.