Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication.

Soares, Jamária A P; Leite, Flávia G G; Andrade, Luciana G; Torres, Alice A; De Sousa, Lirlândia P; Barcelos, Lucíola S; Teixeira, Mauro M; Ferreira, Paulo C P; Kroon, Erna G; Souto-Padrón, Thaís; Bonjardim, Cláudio A

Soares, Jamária A P; Leite, Flávia G G; Andrade, Luciana G; Torres, Alice A; De Sousa, Lirlândia P; Barcelos, Lucíola S; Teixeira, Mauro M; Ferreira, Paulo C P; Kroon, Erna G; Souto-Padrón, Thaís; Bonjardim, Cláudio A.

Affiliation

Soares JA; Grupo de Transdução de Sinal, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil.

J Virol ; 83(13): 6883-99, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19386722

Subject(s)

Cowpox virus/physiology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Vaccinia virus/physiology; Virus Replication; Animals; Apoptosis; Caspase 3/metabolism; Cell Line; Chromones/pharmacology; Cowpox/metabolism; Cowpox virus/drug effects; Cowpox virus/genetics; Gene Expression Regulation, Viral; Mice; Morpholines/pharmacology; Phosphorylation; Poly(ADP-ribose) Polymerases/metabolism; Signal Transduction; Vaccinia/metabolism; Vaccinia virus/drug effects; Vaccinia virus/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccinia virus / Virus Replication / Cowpox virus / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt Limits: Animals Language: En Journal: J Virol Year: 2009 Type: Article Affiliation country: Brazil

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