Synthetic EthR inhibitors boost antituberculous activity of ethionamide.

Willand, Nicolas; Dirié, Bertrand; Carette, Xavier; Bifani, Pablo; Singhal, Amit; Desroses, Matthieu; Leroux, Florence; Willery, Eve; Mathys, Vanessa; Déprez-Poulain, Rebecca; Delcroix, Guy; Frénois, Frédéric; Aumercier, Marc; Locht, Camille; Villeret, Vincent; Déprez, Benoit; Baulard, Alain R

Willand, Nicolas; Dirié, Bertrand; Carette, Xavier; Bifani, Pablo; Singhal, Amit; Desroses, Matthieu; Leroux, Florence; Willery, Eve; Mathys, Vanessa; Déprez-Poulain, Rebecca; Delcroix, Guy; Frénois, Frédéric; Aumercier, Marc; Locht, Camille; Villeret, Vincent; Déprez, Benoit; Baulard, Alain R.

Affiliation

Willand N; Institut National de la Santé et de la Recherche Médicale, Lille, France.

Nat Med ; 15(5): 537-44, 2009 May.

Article in En | MEDLINE | ID: mdl-19412174

Subject(s)

Antitubercular Agents/therapeutic use; Ethionamide/therapeutic use; Oxadiazoles/therapeutic use; Repressor Proteins/antagonists & inhibitors; Repressor Proteins/therapeutic use; Thiophenes/therapeutic use; Tuberculosis/drug therapy; Animals; Binding Sites; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Drug Synergism; Hydrogen Bonding; Ligands; Mice; Models, Molecular; Protein Conformation; Repressor Proteins/chemistry

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Repressor Proteins / Thiophenes / Tuberculosis / Ethionamide / Antitubercular Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2009 Type: Article Affiliation country: France

Fulltext

XML

PubMed Links

Search on Google