[Efficacy of weekly epoetin Beta in the treatment of chemotherapy-induced anemia in solid tumors]. / Efficacité de l'époétine bêta hebdomadaire dans l'anémie des tumeurs solides sous chimiothérapie.
Therapie
; 64(1): 17-25, 2009.
Article
in Fr
| MEDLINE
| ID: mdl-19463249
ABSTRACT
OBJECTIVE:
The aim of the study was to assess the efficacy and safety of epoetin beta once-weekly in anemic patients with solid tumors treated with chemotherapy.METHOD:
Prospective, open-label, multicenter, single-arm study of epoetin beta 30 000 I.U. once-weekly in anemic patients with solid tumors receiving chemotherapy (n = 365).RESULTS:
Epoetin beta increased mean haemoglobin (Hb) levels from 10.3 +/- 0.9 g/dL at baseline to 12.3+/-2.0 g/dL at week 12. The response rate was achieved in 61% (CI 95% 55-68) of the patients. The mean Hb level increased was 1.8 g/dL (CI 95% 1.5-2,0); in lung cancer patients (n = 102) Hb increase was 2.7 g/dL. Treatment with epoetin beta was well tolerated; only 1.4 % patients had thrombotic events.CONCLUSION:
Epoetin beta (30 000 I.U. once weekly) increased Hb levels and was well-tolerated to correct anemia in patients with solid tumors treated with chemotherapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Erythropoietin
/
Anemia
/
Neoplasms
/
Antineoplastic Agents
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Fr
Journal:
Therapie
Year:
2009
Type:
Article
Affiliation country:
France